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Weijian Hang, Chen Chen, Xin A. Zhang, Dao Wen Wang
《医学前沿(英文)》 2021年 第15卷 第4期 页码 638-643 doi: 10.1007/s11684-021-0831-z
关键词: COVID-19 endothelial dysfunction inflammation reaction cytokine storm
Cytokines and inflammation in adipogenesis: an updated review
Ning Jiang, Yao Li, Ting Shu, Jing Wang
《医学前沿(英文)》 2019年 第13卷 第3期 页码 314-329 doi: 10.1007/s11684-018-0625-0
关键词: cytokines inflammation adipogenesis type 2 diabetes mellitus metabolic disorder
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《医学前沿(英文)》 2013年 第7卷 第2期 页码 264-269 doi: 10.1007/s11684-013-0259-1
The effect of the severity of appendiceal inflammation on post-operative stay in children following appendicectomy has shown conflicting results. This study was conducted to determine the association between the severity of appendiceal inflammation and post-operative stay amongst children undergoing open appendicectomy. A retrospective cohort study was conducted at a District General Hospital for two years. A total of 204 patients were included in the study with an age range between 3 and 16 years. Females were 54.9% while the rest were male. Mean age was 12.5±3 years. The association of the severity of appendiceal inflammation and post-operative stay was assessed by multivariable Cox Proportional hazards model. Mean post-operative stay was 2.32 days (95% CI 2.14–2.51). Macroscopically perforated appendix, histological inflammation and post-operative complications were significantly associated with post-operative stay on univariable analysis (P<0.05). Whereas, the multivariable analysis showed that the post-operative stay was significantly prolonged only in case of either perforated appendix or post-operative complications while it remained unaffected by the histological inflammation.
关键词: appendiceal inflammation post-operative stay paediatrics
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《医学前沿(英文)》 2017年 第11卷 第3期 页码 349-358 doi: 10.1007/s11684-017-0571-2
Peritoneal dialysis (PD) is an established form of renal replacement therapy. Long-term PD leads to morphologic and functional changes to the peritoneal membrane (PM), which is defined as peritoneal fibrosis, a known cause of loss of peritoneal ultrafiltration capacity. Inflammation and angiogenesis are key events during the pathogenesis of peritoneal fibrosis. This review discusses the pathophysiology of peritoneal fibrosis and recent research progress on key fibrogenic molecular mechanisms in peritoneal inflammation and angiogenesis, including Toll-like receptor ligand-mediated, NOD-like receptor protein 3/interleukin-1β, vascular endothelial growth factor, and angiopoietin-2/Tie2 signaling pathways. Furthermore, novel strategies targeting peritoneal inflammation and angiogenesis to preserve the PM are discussed in depth.
关键词: peritoneal dialysis peritoneal fibrosis inflammation angiogenesis
《医学前沿(英文)》 2021年 第15卷 第5期 页码 750-766 doi: 10.1007/s11684-021-0839-4
关键词: particulate matter 2.5 sirtuin 2 p65 airway inflammation bronchial hyperresponsiveness triptolide
YANG Jurong, HE Yani, SHEN Haiying, DING Hanlu, LI Kailong, WANG Huiming
《医学前沿(英文)》 2008年 第2卷 第1期 页码 25-34 doi: 10.1007/s11684-008-0006-1
Inflammation and liver tumorigenesis
null
《医学前沿(英文)》 2013年 第7卷 第2期 页码 242-254 doi: 10.1007/s11684-013-0256-4
Inflammation has been considered as one of the hallmarks of cancer, and chronic hepatitis is a major cause of liver cancer. This review will focus on the pathogenic role of inflammation in hepatocarcinogenesis and will discuss recent advances in understanding the chronic hepatitis-liver cancer link based on hot spots in liver cancer research, including cellular interaction, cytokines, microRNA and stem cells. All of these mechanisms should be taken into consideration because they are crucial for the development of more efficacious therapeutic strategies for preventing and treating human chronic hepatitis and hepatocellular carcinoma.
关键词: hepatocellular carcinoma hepatitis cytokine stem cell miRNA
Discovery and repurposing of artemisinin
《医学前沿(英文)》 2022年 第16卷 第1期 页码 1-9 doi: 10.1007/s11684-021-0898-6
关键词: artemisinin drug repurposing cancer inflammation COVID-19 traditional Chinese medicine
Plasma transthyretin is a nutritional biomarker in human morbidities
《医学前沿(英文)》 2022年 第16卷 第4期 页码 540-550 doi: 10.1007/s11684-022-0940-3
关键词: lean body mass nutritional status transthyretin malnutrition inflammation amyloidosis
《化学科学与工程前沿(英文)》 2022年 第16卷 第12期 页码 1700-1712 doi: 10.1007/s11705-022-2207-6
关键词: naphtha catalytic pyrolysis reaction pathway equilibrium yield
Mechanisms of insulin resistance in obesity
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 14-24 doi: 10.1007/s11684-013-0262-6
Obesity increases the risk for type 2 diabetes through induction of insulin resistance. Treatment of type 2 diabetes has been limited by little translational knowledge of insulin resistance although there have been several well-documented hypotheses for insulin resistance. In those hypotheses, inflammation, mitochondrial dysfunction, hyperinsulinemia and lipotoxicity have been the major concepts and have received a lot of attention. Oxidative stress, endoplasmic reticulum (ER) stress, genetic background, aging, fatty liver, hypoxia and lipodystrophy are active subjects in the study of these concepts. However, none of those concepts or views has led to an effective therapy for type 2 diabetes. The reason is that, there has been no consensus for a unifying mechanism of insulin resistance. In this review article, literature is critically analyzed and reinterpreted for a new energy-based concept of insulin resistance, in which insulin resistance is a result of energy surplus in cells. The energy surplus signal is mediated by ATP and sensed by adenosine monophosphate-activated protein kinase (AMPK) signaling pathway. Decreasing ATP level by suppression of production or stimulation of utilization is a promising approach in the treatment of insulin resistance. In support, many of existing insulin sensitizing medicines inhibit ATP production in mitochondria. The effective therapies such as weight loss, exercise, and caloric restriction all reduce ATP in insulin sensitive cells. This new concept provides a unifying cellular and molecular mechanism of insulin resistance in obesity, which may apply to insulin resistance in aging and lipodystrophy.
关键词: type 2 diabetes energy expenditure inflammation lipotoxicity mitochondria hyperinsulinemia adenosine monophosphate-activated protein kinase (AMPK)
《医学前沿(英文)》 2022年 第16卷 第5期 页码 667-685 doi: 10.1007/s11684-022-0960-z
关键词: Akkermansia muciniphila NAFLD NASH steatosis inflammation
null
《医学前沿(英文)》 2015年 第9卷 第2期 页码 139-145 doi: 10.1007/s11684-015-0377-z
In obesity, chronic inflammation is believed to induce insulin resistance and impairs adipose tissue function. Although this view is supported by a large body of literature, it has been challenged by growing evidence that pro-inflammatory cytokines may favor insulin sensitivity through induction of energy expenditure. In this review article, interleukin 15 (IL-15) is used as a new example to explain the beneficial effects of the pro-inflammatory cytokines. IL-15 is secreted by multiple types of cells including macrophages, neutrophils and skeletal muscle cells. IL-15 expression is induced in immune cells by endotoxin and in muscle cells by physical exercise. Its transcription is induced by transcription factor NF-κB. IL-15 binds to its receptor that contains three different subunits (α, β and γ) to activate JAK/STAT, PI3K/Akt, IKK/NF-κB and JNK/AP1 pathways in cells. In the regulation of metabolism, IL-15 reduces weight gain without inhibiting food intake in rodents. IL-15 suppresses lipogenesis, stimulates brown fat function, improves insulin sensitivity through weight loss and energy expenditure. In human, circulating IL-15 is negatively associated with body weight. In the immune system, IL-15 stimulates proliferation and differentiation of T cells, NK cells, monocytes and neutrophils. In the anti-obesity effects of IL-15, T cells and NK cells are not required, but leptin receptor is required. In summary, evidence from human and rodents supports that the pro-inflammatory cytokine IL-15 may enhance energy expenditure to protect the body from obesity and type 2 diabetes. The mechanism of IL-15 action remains to be fully uncovered in the regulation of energy expenditure.
关键词: inflammation obesity cytokine energy expenditure insulin resistance
Heterogeneous reaction mechanism of gaseous HNO
Nan ZHAO,Qingzhu ZHANG,Wenxing WANG
《环境科学与工程前沿(英文)》 2016年 第10卷 第5期 doi: 10.1007/s11783-016-0836-z
关键词: Seasalt particles NaCl HNO3 Heterogeneous reaction Reaction mechanism Density functional theory
标题 作者 时间 类型 操作
Endothelial dysfunction in COVID-19 calls for immediate attention: the emerging roles of the endothelium in inflammation
Weijian Hang, Chen Chen, Xin A. Zhang, Dao Wen Wang
期刊论文
Cytokines and inflammation in adipogenesis: an updated review
Ning Jiang, Yao Li, Ting Shu, Jing Wang
期刊论文
Appendiceal inflammation affects the length of stay following appendicectomy amongst children: a myth
null
期刊论文
for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on peritoneal inflammation
null
期刊论文
Particulate matter 2.5 triggers airway inflammation and bronchial hyperresponsiveness in mice by activating
期刊论文
Expression of renal cubilin and its potential role in tubulointerstitial inflammation induced by albumin
YANG Jurong, HE Yani, SHEN Haiying, DING Hanlu, LI Kailong, WANG Huiming
期刊论文
Thermodynamic analysis of reaction pathways and equilibrium yields for catalytic pyrolysis of naphtha
期刊论文
Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge and perspectives
期刊论文
Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes
null
期刊论文